Targeted brain delivery of methotrexate by glutathione PEGylated liposomes: How can the formulation make a difference? ScienceDirect Leucovorin (Folinic Acid) The Rescue Drug! Pearl:Leucovorin (Folinic Acid) is Methotrexate's antidote. It is the reduced form of folate that can bypass the enzyme dihydrofolate reductase (which Methotrexate inhibits). Application: It GlutathioneResponsive Methotrexate Polymersomes for Potential Management of Ectopic Pregnancy Mamnoon 2024 Small Wiley Online Library Epicatechin ameliorative effects on methotrexate induced hepatotoxicity in mice Reza Azadnasab, Hadi Kalantar, Layasadat Khorsandi, Heibatullah Kalantari, Mohammad Javad Khodayar, 2021